Pragmatic considerations for negative control outcome studies to guide non-randomized comparative analyses: A narrative review.

Sara N Levintow,Carrie M Nielson,Rohini K Hernandez,Alexander Breskin, David Pritchard,Timothy L Lash,Kenneth J Rothman,David Gilbertson,Paul Muntner,Cathy Critchlow,M Alan Brookhart,Brian D Bradbury

Pharmacoepidemiology and drug safety（2023）

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摘要

Given the increasing use of non-randomized designs for regulatory decision-making, the application of NCO methods will strengthen study design, analysis, and interpretation of real-world data and the credibility of the resulting real-world evidence.

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关键词

comparative effectiveness,comparative safety,healthcare databases,negative control,pharmacoepidemiology,residual confounding

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