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    • Image-derived Input Function in Brain [18F]FDG PET Data: Which Alternatives to the Carotid Siphons?

    Erica Silvestri,Tommaso Volpi,Andrea Bettinelli,Mattia De Francisci,Judson Jones,Maurizio Corbetta,Diego Cecchin,Alessandra Bertoldo

    2022 44th Annual International Conference of the IEEE Engineering in Medicine &amp Biology Society (EMBC)（2022）

    University of Padua

    Cited 4|Views15
    Abstract
    Quantification of brain [18F] fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET) data requires an input function. A noninvasive alternative to gold-standard arterial sampling is the image-derived input function (IDIF), typically extracted from the internal carotid arteries (ICAs), which are however difficult to segment and subjected to spillover effects. In this work, we evaluated the feasibility of extracting the IDIF from two different vascular sites, i.e., 1) common carotids (CCA) and 2) superior sagittal sinus (SSS), other than 3) ICA in a large group of glioma patients undergoing a dynamic [18F]FDG PET acquisition on a hybrid PET/MR scanner. Comparisons are drawn between the different IDIFs in terms of peak amplitude and shape, as well as between the estimates of fractional uptake rate (Kr) obtained from the different extraction sites in terms of a) grey/white matter average absolute values, b) ratio of grey-to-white matter, and c) spatial patterns for the hemisphere contralateral to the lesion. Clinical Relevance - This work points towards new feasible IDIF extraction sites (CCA in particular) which could allow for fully noninvasive absolute PET quantification in clinical populations.
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    Key words
    Algorithms,Brain,Carotid Artery, Internal,Fluorodeoxyglucose F18,Humans,Positron-Emission Tomography
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