H型高血压患者HDL亚组分的改变及对内皮细胞抗炎功能的影响
Chinese Journal of Arteriosclerosis（2022）
Abstract
目的 观察H型高血压患者血同型半胱氨酸水平(Hcy)与高密度脂蛋白(HDL)亚组分的相关性,并研究HDL亚组分对内皮细胞抗炎功能的影响.方法 选取健康人群133例、单纯高血压患者76例、H型高血压患者85例,测定空腹血糖(FBG)、血清肌酐(SCr)、尿酸(UA)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDLC)、HDL2、HDL3和Hcy等指标.分别留取各组血清各6例,应用快速蛋白液相色谱法(FPLC)提取大颗粒HDL(L-HDL),观察L-HDL对肿瘤坏死因子α(TNF-α)诱导的人脐静脉内皮细胞(HUVEC)炎症的改善作用.结果 健康对照组、单纯高血压组和H型高血压组UA、FBG、TC、LDLC水平差异无统计学意义(P＞0.05).对比单纯高血压患者和健康对照组,H型高血压患者具有更低的HDLC、HDL2水平及更高的HDL3水平(P＜0.001);血Hcy水平与血HDLC、HDL2呈显著负相关(P＜0.01),但是与HDL3无显著相关性(P=0.083).健康对照组、单纯高血压组L-HDL均可下调TNF-α诱导的血管内皮细胞表达血管细胞黏附分子1(VCAM-1),而H型高血压组L-HDL并不能明显减低VCAM-1表达.结论 H型高血压患者可能通过高Hcy影响HDL的亚组分分布以及L-HDL对内皮细胞的抗炎功能.
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