Abstract 1687: Expression of DAB2IP is related with cancer progression and prognosis of gastric cancer

Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Background: Gastric cancer remains the fourth most common cancer and the second leading cause of cancer-related death worldwide. DAB2IP, a novel member of the Ras GTPase-activating protein family, is down-regulated in various human cancers and functions as a bona fide tumor suppressor in cancer development. In gastric cancer, the expression of DAB2IP and its relation to tumor progression and prognosis has not been investigated. Therefore, we undertook a clinicpathologic study of gastric cancer to investigate the correlation between the expression of DAB2IP and clinical characteristics. Results: Immunohistochemistry was performed in 120 cases of gastric cancer tissues and corresponding adjacent normal mucosas, 36 cases of non-metastatic lymph node and 68 cases of metastatic lymph node. Overall results showed that 69 of 104 gastric cancer tissues expressed low level of DAB2IP, and 94 of 104 adjacent normal mucosas expressed high level of DAB2IP. We also scored the expression level of DAB2IP based on both the intensity of staining and the percentage of positive cell… The expression of DAB2IP in gastric cancer tissues or lymphatic metastatic tissues was clearly lower than that in normal mucosas (p<0.01). DAB2IP expression was obviously decreased in gastric cancer tissues with lymphatic metastasis compared to those without lymphatic metastasis (p<0.01). The expression of DAB2IP was correlated with gender, serosal invasion, lymphatic metastasis, remote metastasis, tumor grade, and carcinoembryonic antigen (CEA) levels (p<0.05). DAB2IP expression appears to be an independent prognostic marker for survival of patients with gastric cancer (p<0.05). Patients with lower expression of DAB2IP had worse overall survival than those with higher expression of DAB2IP (p<0.01). Conclusions: DAB2IP is a potential new marker for predicting the progression and prognosis of gastric cancer. Loss of DAB2IP expression is related with poor overall survival of patients in gastric cancer, indicating its potent role in gastric carcinogensis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1687. doi:1538-7445.AM2012-1687