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    • 不同剂量布地奈德对AECOPD患者肺功能和PCT、MMP-9及TIMP-1水平的影响

    田祥,刘素芬,付晓丽,王丽显,张冬芹

    Journal of Molecular Diagnosis and Therapy（2021）

    Cited 3|Views6
    Abstract
    目的 分析肺功能和血清降钙素原(PCT)、基质金属蛋白酶-9(MMP-9)及金属蛋白酶-1组织抑制因子(TIMP-1)水平在慢性阻塞性肺疾病急性加重期(AECOPD)患者治疗中的变化.方法 选取2017年12月至2019年12月本院收治的AECOPD患者120例,根据不同治疗剂量分为低剂量组(1 mg/次布地奈德)及高剂量组(2 mg/次布地奈德)各60例.比较两组患者临床疗效、肺功能、动脉血气指标、PCT、MMP-9及TIMP-1水平及不良反应发生情况.结果 高剂量组患者总有效率明显高于低剂量组(96.67％vs 75.00％),差异有统计学意义(P<0.05).治疗前,两组患者FEV1、FVC、FEV1/FVC、SaO2、PaCO2、PaO2、PCT、MMP-9及TIMP-1水平比较差异均无统计学意义(P>0.05).治疗后,两组患者FEV1、FVC、FEV1/FVC、SaO2、PaCO2、PaO2水平均较治疗前上升,PCT、MMP-9及TIMP-1水平较治疗前降低,以高剂量组尤甚,差异有统计学意义(P<0.05).高剂量组与低剂量组不良反应比较差异无统计学意义(χ2=2.143,P=0.143).结论 予以2 mg/次布地奈德治疗AECOPD患者临床疗效显著,可有效改善肺功能及血气指标,降低PCT、MMP-9及TIMP-1水平.
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