Development and Validation of the Immunohistochemical Signature to Predict the Prognosis Value in Patients with Esthesioneuroblastoma
SSRN Electronic Journal（2021）
Abstract
Purpose: The objective of this study was to develop and validate the immunohistochemistry (IHC) signature to predict the clinical outcome in patients with Esthesioneuroblastoma (ENB).Methods: A total of 131 patients with previously untreated, nonmetastatic ENB were included in this retrospective study. Lasso-penalized multivariate cox survival model was constructed to establish the IHC signature related to overall survival (OS) in the training cohort (n = 80) with cross-validation, which was later verified using the validation set (n = 51). Moreover, this study incorporated the IHC signature in constructing a nomogram for OS prediction.Results: The IHC signature consisting of three IHC features (CK, Ki67, Syn) can divide cases as a low-or high-risk group based on the IHC scores. The 5-year OS rate of low-risk group in training set 84.8% (95% confidence interval [CI]: 65.2-100%) , while that of high-risk group was 41.2% (95% CI: 28.9–53.5%; P = 0.001); as for validation set, those in high-and low-risk groups were 42.3% (95% CI: 24.5–60.1%) and 83.0% (95% CI: 65.4–100%), respectively (P = 0.002). Multivariable analysis showed that the IHC-based nomogram served as a factor to independently predict OS (P＜0.05). A nomogram was constructed to incorporate clinicopathological risk factors (e.g., age, T stage, and N stage) and the IHC score to calculate 3-, 5-, and 10-year OS probability. Conclusions: Our nomogram has proven to be of immense clinical use. Our IHC classifier incorporating three IHC markers could be beneficial in clinical decision-making and identify optimal treatment strategies for patients with ENB.Funding Statement: This study was mainly funded by the Natural Science Foundation of Guangdong Province of China (2021A1515010853)Declaration of Interests: The authors declare that they have no actual or potential conflicts of interest.Ethics Approval Statement: This study was approved by the Ethics Committee of Sun Yat-Sen University Cancer Center, China.
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