结肠癌预后发生miR-21高表达的直接相关性分析
China Medical Engineering(2015)
Abstract
目的 探讨分析结肠癌预后发生miR-21高表达的直接相关性.方法 选取我院2011年7月-2012年8月手术切除结肠癌患者50例为研究对象,通过TaqMan实时定量RT-PCR法对该组患者中的结肠癌组织miR-21的高表达检测,并且将癌旁正常组织miR-21的表达进行比较观察,进而对结直肠癌临床病理因素与预后发生miR-21的高表达之间的关系加以分析.结果 通过与对比癌旁正常组织miR-21的高表达相比较可以得出,结肠癌组织miR-21的表达明显要高很多,差异具有统计学意义(P<0.05).结肠癌预后发生miR-21的表达与患者的性别、年龄、肿瘤部位等情况关联较小,却与肿瘤病理学分级、淋巴结转移、术后生存率三个方面有着紧密的联系.结论 结肠癌组织miR-21的表达要高于正常组织,同时它可能与大肠癌的发生及肿瘤的生长有着密切的联系.
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