T2*mapping定量评估肾脏缺血再灌注损伤动态变化的可行性
Chinese Journal of Radiology（2019）
Abstract
探讨T2*mapping技术定量评价肾脏缺血再灌注损伤(IRI)后不同时间点动态变化的可行性.方法 选取新西兰大白兔18只,采用无创血管夹夹闭左侧肾蒂60 min后松开建立IRI模型.分别于建模前及建模后1、12、24、48 h行左肾轴面T2WI和T2*mapping扫描,在建模后1、12、24 h选取2只兔处死,其余10只兔在48 h后处死,对细胞水肿、细胞坏死、间质炎症及管型等进行病理分级评分.测量左肾内髓、外髓和皮质的T2*值及R2*值.用重复测量方差分析比较肾脏各部位5个时间点间T2*值的差异,并对各时间点T2*值、R2*值与对应的病理评分进行Spearman相关分析.结果 建模前及建模后1、12、24、48 h的内髓、外髓T2*值及R2*值差异均有统计学意义(P<0.05),皮质T2*值和R2*值差异均无统计学意义(P>0.05).细胞坏死、间质炎症和管型评分则随着IRI的发展逐渐增长,IRI后外髓的T2*值与对应区域的细胞水肿、间质炎症及管型评分呈正相关(r值分别为0.57、0.38、0.33,P均<0.05);外髓R2*值与对应区域的细胞水肿呈负相关(r=-0.52,P<0.05).结论 T2*mapping可反映肾脏IRI后不同区带、不同时间点的动态变化,其中以外髓带最为明显,并与病理评分存在较好的一致性.
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Key words
Magnetic resonance imaging,Reperfusion injury,T2*mapping
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