Polystyrene Nanoplastics Trigger Pyroptosis in Dopaminergic Neurons Through TSC2/TFEB-mediated Disruption of Autophagosome-Lysosome Fusion in Parkinson’s Disease

Xiaomei Liang, Yaqi Zeng,Piao Zhang, Baoyu Zhu, Jiezhu Feng, Tongtong Deng, Zhongling Fu, Chengshuai Liu,Chengyu Chen,Yuhu Zhang

Journal of Translational Medicine（2025）

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关键词

Polystyrene nanoplastics (PS-NPs),Parkinson’s disease (PD),Pyroptosis,Tuberous Sclerosis Complex 2 protein (TSC2),Autophagosome-lysosome fusion

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