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Higher Order Receptor Clustering Due to the IgG3 Subclass is Necessary for TLR4 Signaling and Tolerance Induction by Novel Human Anti-Tlr4 Antibodies

Luke S Heuer, Nicolle Sweeney,Manuel Rojas,Weici Zhang,Andrew R Mendelsohn,Manley Huang, Bo Yu, Paulina Ackerman, Qisheng Wei,Andrew B Herr, James W Larrick,William M Ridgway

mAbs（2025）

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关键词
Aggregation,hexamers,IgG3,receptor clustering,TLR4 agonist,tolerance
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