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Preparation and Characterization of Ternary Complexes to Improve the Solubility and Dissolution Performance of a Proteolysis-Targeting Chimera Drug

Heng Zhang, Hengqian Wu, Lili Wang, Laura Machín Galarza, Chuanyu Wu,Mingzhong Li,Zhengping Wang, Erpeng Zhou,Jun Han

Pharmaceutics(2025)

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Key words
proteolysis targeting chimeras (PROTACs),sulfobutyl ether-β-cyclodextrin,vitamin E-TPGS,ternary complex,dissolution enhancement
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