Conformational Restriction Enables Discovering a Series of Chroman Derivatives As Potent and Selective NaV1.8 Inhibitors with Improved Pharmacokinetic Properties.

Na Li, Linlin Wang, Xinyuan Hu,Haiyan Xu,Bowen Yang,Li Zhan, Yongjie Cai, Yueling Gu,Xueqin Chen,Yueming Zheng, Tongchao Liu,Zhaobing Gao,Bing Xiong

European journal of medicinal chemistry（2025）

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