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Generating Potent and Persistent Antitumor Immunity Via Affinity-Tuned CAR-T Cells Targeting Mesothelin

Ya-Li Yue, Jun-Jun Liu,Hang Ma, Zhi-di Pan,Lei Wang, Jia-Wei Zhang, Shu-Sheng Wang,Yue-Qing Xie,Hua Jiang,Yan-Lin Bian,Ming-Yuan Wu,Yun-Sheng Yuan,Bao-Hong Zhang,Xiao-Dong Xiao,Jian-Wei Zhu

Acta pharmacologica Sinica(2025)

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Key words
solid tumors,chimeric antigen receptor,mesothelin,affinity-tuned,tumor recurrence,LP12 CAR-T cells
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