Modulating the CXCR2 Signaling Axis Using Engineered Chemokine Fusion Proteins to Disrupt Myeloid Cell Infiltration in Pancreatic Cancer

Benjamin N Christopher, Lena Golick, Ashton Basar,Leticia Reyes, Reeder M Robinson, Aaron O Angerstein,Carsten Krieg, G Aaron Hobbs, Denis C Guttridge,John P O'Bryan,Nathan G Dolloff

Biomolecules（2025）

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Key words

pancreatic ductal adenocarcinoma,tumor microenvironment,immunosuppression,myeloid cell migration,MDSCs,CXCR2,CXCL1

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