Modulation of Senescent Lepr+ Skeletal Stem Cells Via Suppression of Leptin-Induced STAT3‒FGF7 Axis Activation Alleviates Abnormal Subchondral Bone Remodeling and Osteoarthritis Progression

Fu-Hao Yu, Bo-Feng Yin, Ming-Yu Liu, Wen-Jing Zhang, Zhi-Dong Zhao, Lei Wang, Xiao-Tong Li, Pei-Lin Li, Zhi-Ling Li, Run-Xiang Xu,Li Ding,Heng Zhu

Stem Cell Research & Therapy（2025）

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Key words

Osteoarthritis,Single-cell sequencing,Skeletal stem cells,Heterogeneity of Cellular senescence,Leptin-Lepr signaling,STAT3-FGF7 axis

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