Synthesis and Evaluation of Isoquinolinyl and Pyridinyl-Based Dual Inhibitors of Fatty Acid Amide Hydrolase and Soluble Epoxide Hydrolase to Alleviate Orofacial Hyperalgesia in the Rat.

Daniel Carr, Siena Gunari, Gabrielle Gorostiza, Madison Mercado, Lucy Pavana, Leah Duong, Karen Gomez, Steve Salinas, Coral Garcia, Amanda Tsang,Christophe Morisseau, Bruce D Hammock,Stevan Pecic,Ram Kandasamy

Biochemistry and biophysics reports（2025）

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Key words

Polypharmacology,Formalin,Orofacial,Enzyme inhibition,Structure-activity relationship studies

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