Intrastriatal Injection of Alpha-Synuclein Preformed Fibrils to Rats Results in L-DOPA Reversible Sensorimotor Impairments and Alterations in Non-Motor Function

Sheila M Fleming, Sophia Scott, Edward J Hamad, Danielle E Herman,John G Holden,Lily Yan, Katrina Linning-Duffy, Christopher J Kemp,Joseph R Patterson, Kathryn M Miller, Michael Kubik, Nathan Kuhn,Anna C Stoll,Megan F Duffy,Kathy Steece-Collier, Allyson Cole-Strauss, Jack W Lipton,Kelvin C Luk,Caryl E Sortwell

Frontiers in neuroscience（2025）

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Key words

Parkinson’s disease,cognitive function,dopamine,bradykinesia,nigrostriatal

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