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Functional Role of Fatty Acid Synthase for Signal Transduction in Core-Binding Factor Acute Myeloid Leukemia with an Activating C-Kit Mutation

Ruimeng Zhuang, Bente Siebels, Konstantin Hoffer,Anna Worthmann,Stefan Horn, Nikolas Christian Cornelius von Bubnoff,Cyrus Khandanpour,Niklas Gebauer,Sivahari Prasad Gorantla, Hanna Voss,Hartmut Schlüter,Malte Kriegs,Walter Fiedler,Carsten Bokemeyer, Manfred Jücker,Maxim Kebenko

Biomedicines(2025)

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关键词
fatty acid synthase,palmitoylation,TVB-3166,AML,c-Kit mutation,PI3K,Akt,mTOR,S6 kinase,Lyn,Gli1,hedgehog signaling
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