Improvement in Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P4503A Time-Dependent Inhibitors Through in Vitro Allosteric Modulation by Progesterone

Pooja Hegde, Brianna Rodriguez, Alec Bell,Stephen D. Hall,Luc R. A. Rougee

DRUG METABOLISM AND DISPOSITION（2025）

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关键词

Time-dependent inhibition,Allosteric modulation,Drug-drug interaction,Risk-prediction,Dynamic and mechanistic static models

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