Unveiling the Intriguing Relationship: Oncogenic KRAS, Morphological Shifts, and Mutational Complexity in Pancreatic Mucinous Cystic Neoplasms

Annika Schulte,Annika Beck,Ralf Marienfeld,Ninel Azoitei, Thomas Barth,Alica Beutel,Vladimir Benes,Markus Buechler, Nadine Gaisa, Katja Kilani,Nathalia Giese,Christoph W. Michalski,Peter Moeller,Lukas Perkhofer,Tobias Rausch,Stefan Repky,Elodie Roger,Jeanette Scheible,Thomas Seufferlein,Peter Schirmacher, Alexander Berger,Thilo Hackert,Alexander Kleger

JOURNAL OF PATHOLOGY（2025）

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Key words

pancreatic ductal adenocarcinoma (PDAC),mucinous cystic neoplasms (MCN),KRAS mutations,intratumor heterogeneity,variant allele frequency (VAF),circulating tumor DNA (ctDNA),tumor progression,mutational landscape

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