Engineered Commensals for Targeted Nose-to-brain Drug Delivery

Haosheng Shen,Nikhil Aggarwal, Beiming Cui, Guo Wei Foo, Yuanzhi He, Santosh Kumar Srivastava, Shengjie Li, Marcus Ze Xian Seah,Kwok Soon Wun,Hua Ling,In Young Hwang,Chun Loong Ho, Yung Seng Lee,Matthew Wook Chang

Cell（2025）

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Key words

brain drug delivery,intranasal delivery,olfactory epithelium,blood-brain barrier,central nervous system,nasal commensals,Lactobacillus plantarum,obesity,synthetic biology

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