The Lactate‐Primed KAT8‒PCK2 Axis Exacerbates Hepatic Ferroptosis During Ischemia/Reperfusion Injury by Reprogramming OXSM‐Dependent Mitochondrial Fatty Acid Synthesis

Jingsheng Yuan, Mingyang Yang, Zhenru Wu, Jun Wu, Kejie Zheng, Jiaguo Wang, Qiwen Zeng, Menglin Chen,Tao Lv,Yujun Shi,Jiayin Yang,Jian Yang

ADVANCED SCIENCE（2025）

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关键词

ferroptosis,hepatic ischemia-reperfusion injury,lactate,lactylation,metabolic reprogramming,mitochondrial fatty acid synthesis,phosphoenolpyruvate carboxykinase 2

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