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Cotargeting of Thioredoxin 1 and Glutamate-Cysteine Ligase in Both Imatinib-Sensitive and Imatinib-Resistant CML Cells

Xiaoyan Sun, Chunli Zhang,Bo Fan,Qingyu Liu, Xiaofeng Shi, Shuxia Wang,Ting Chen,Xueting Cai,Chunping Hu,Handong Sun,Pematenzin Puno,Peng Cao

BIOCHEMICAL PHARMACOLOGY(2025)

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Key words
thioredoxin,glutathione,chronic myeloid leukemia,ferroptosis,combinational strategy
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