Design, Synthesis, and Biological Evaluation of Flavokavain B Derivatives As Potent TRF2 Inhibitors for the Treatment of Osteosarcoma

Kun Wang, Changgui Shi, Lu Liu,Hao Yan, Dalong Wang, Meiqing Ding, Jiaying Tong, Yeying He, Yina Hu, Chaoyue Chen, Di Cao, Fangjun Zhang,Xiaohui Zheng,Zhiguo Liu

European journal of medicinal chemistry（2025）

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Key words

Telomere repeat-binding factor 2,Flavokavain B derivative,Osteosarcoma,Anticancer activity

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