Probing the Functional Constraints of Influenza A Virus NEP by Deep Mutational Scanning

Qi Wen Teo,Yiquan Wang,Huibin Lv,Michael S. Oade, Kevin J. Mao,Timothy J.C. Tan, Yang Wei Huan,Joel Rivera-Cardona, Evan K. Shao,Danbi Choi, Chaoyang Wang,Zahra Tavakoli Dargani,Christopher B. Brooke,Aartjan J.W. te Velthuis,Nicholas C. Wu

Cell Reports（2025）

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关键词

influenza virus,NS1,nuclear export protein,NEP,evolutionary constraints,the transcription-to-replication switch,innate immune response,cellular apoptosis,mammalian adaptation of avian influenza virus

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