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Discovery of HZS60 As a Novel Brain Penetrant NMDAR/TRPM4 Interaction Interface Inhibitor with Improved Activity and Pharmacokinetic Properties for the Treatment of Cerebral Ischemia.

Meiling Sun,Lin Wang, Qiaofeng Cao, Xuechun Wang, Ying Zhang, Manyu Guo, Jie Chen, Yuchen Ma, Le Niu, Yanping Zhang, Mengdie Hu, Mengli Gu, Zhihui Zhu, Xinyi Yao, Junchen Yao,Chen Zhao,Jin Wu,Xiuxiu Liu,Yingmei Lu,Zhen Wang,Qiuping Xiang, Feng Han, Dongsheng Zhu

JOURNAL OF MEDICINAL CHEMISTRY（2025）

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