Design of Potent Menin-KMT2A Interaction Inhibitors with Improved in Vitro ADME Properties and Reduced Herg Affinity.
Bruno D. Chapsal, Jennifer R. Kimbrough,Stephanie M. Bester, Alex Bergstrom, Donald S. Backos, Bismarck Campos,Matthew G. Mcdonald, Rebecca Abrahamsen, Andrew C. Allen, Patrick M. Doerner Barbour, Tanna Bettendorf,Mark L. Boys, Karin Brown,Mark J. Chicarelli,Adam W. Cook, Amy L. Crooks, Cole L. Cruz, Joshua R. Dahlke, Alida Eide,Jay B. Fell, Jennifer L. Fulton, Matthew Gargus,John J. Gaudino, Anna L. Guarnieri, Erik P. Hansen, Melissa C. Holt, Dean R. Kahn,Ellen R. Laird, Paul D. Larsen, Rebecca Linwood,Matthew C. Martinson, Joseph Mccown,Macedonio J. Mejia, David A. Moreno,Tung-Chung Mou,Brad Newhouse,Jacob M. O'Leary,Martha E. Rodriguez,Anurag Singh, Lenka Sinik, Keith A. Strand, Eric E. Touney, Lance A. Wollenberg,Jim Wong,Yeyun Zhou,John P. Fischer,Shelley Allen ACS MEDICINAL CHEMISTRY LETTERS（2024）
Key words
Menin,KMT2A,MLL,NPM1m,hERG
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