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Synthesis and Functional Screening of Novel Inhibitors Targeting the HDAC6 Zinc Finger Ubiquitin-Binding Domain

Silke Geurs, Eleni Staessens,Kato Bredael, Stefaan Borghgraef, Jordy De Ridder,Leentje Persoons,Steven De Jonghe,Dominique Schols,Mandeep K. Mann,Rachel J. Harding,Jorick Franceus,Tom Desmet,Kristof Van Hecke,Dorien Clarisse,Karolien De Bosscher,Matthias D'hooghe

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY（2025）

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Key words
Histone deacetylase 6 (HDAC6),HDAC6 ubiquitin-binding domain,Aggresome,Multiple myeloma,Antiviral activity
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