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Tumor-derived G-CSF Induces an Immunosuppressive Microenvironment in an Osteosarcoma Model, Reducing Response to CAR.GD2 T-cells

Michele Pezzella,Concetta Quintarelli, Maria C. Quadraccia,Andrea Sarcinelli,Simona Manni,Laura Iaffaldano,Alessio Ottaviani,Roselia Ciccone,Antonio Camera, Maria L. D’Amore,Stefano Di Cecca,Matilde Sinibaldi,Marika Guercio,Mariasole Aurigemma, Pamela De Falco, Valentina Fustaino,Rossella Rota,Silvia Pomella,Matteo Cassandri,Angela Di Giannatale,Chiara Agrati,Veronica Bordoni, Federica Guarracino,Michele Massa,Giada Del Baldo,Marco Becilli,Giuseppe M. Milano,Francesca Del Bufalo,Franco Locatelli,Biagio De Angelis

Journal of Hematology & Oncology（2024）

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关键词
GD2,Chimeric antigen receptor (CAR),Sarcoma,ICasp9.2A.GD2.CAR-CD28.4–1BBζ,CAR.GD2 T-cells,EZH2 inhibitor,Myeloid-derived suppressor cells,CXCL8,G-CSF
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