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Integrating Binding Affinity and Tonic Signaling Enables a Rational CAR Design for Augmented T Cell Function

Markus Barden, Patrick Ronan Elsenbroich, Vivian Haas,Moritz Ertelt, Philip Pervan,Lukas Velas, Bence Gergely,Arpad Szoeor,Dennis Christoph Harrer,Valerie Bezler,Astrid Holzinger, Rasmus Ulslev Wegener Friis,Gyorgy Vereb,Gerhard J. Schuetz,Clara T. Schoeder,Andreas A. Hombach,Hinrich Abken

JOURNAL FOR IMMUNOTHERAPY OF CANCER（2024）

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Key words

T cell,Chimeric antigen receptor - CAR,Immunotherapy

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