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EGFR-V834L Combined with L858R Mutation Reduced Afatinib Sensitivity and Associated to Early Recurrence in Lung Cancer

Nanao Terada,Hayato Koba,Shigeki Nanjo,Hideharu Kimura,Akihiro Nishiyama,Taro Yoneda,Takayuki Takeda,Hiroki Shirasaki,Koichi Nishi,Takashi Sone,Tadaaki Yamada,Koichi Takayama,Kazuhiko Shibata,Hiroki Matsuoka,Toshiyuki Kita,Kazuhiro Nagata,Yuichi Tambo,Noriyuki Ohkura,Johsuke Hara,Kazuo Kasahara,Shinji Kohsaka,Hiroyuki Mano,Seiji Yano

TRANSLATIONAL LUNG CANCER RESEARCH（2024）

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Key words
Co-mutation,epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI),resistance,liquid biopsy,cell-free DNA (cfDNA)
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