An Engineered Cereblon Optimized for High Throughput Screening and Molecular Glue Discovery

Henry J. Bailey,Jonathan Eisert, Rubina Kazi, Jan Gerhartz, Dominika Ewa Pieńkowska, Ina Dressel, Joshua Vollrath,Ivan Kondratov, Tetiana Matviyuk,Nataliya Tolmachova, Varun Jayeshkumar Shah, Giulio Giuliani, Thorsten Mosler, Thomas M. Geiger, Ana M. Esteves,Sandra P. Santos, Raquel L. Sousa,Tiago M. Bandeiras, Eva-Maria Leibrock, Ulrike Bauer

Cell Chemical Biology（2024）

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molecular glues,cereblon,targeted protein degradation,IMiDs,PROTACs,degraders,ubiquitin

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