Discovery of 4-(5-membered)heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

Elizabeth S. Childress,Rory A. Capstick, Katherine E. Crocker, Miranda L. Ledyard,Aaron M. Bender, Mallory A. Maurer, Natasha B. Billard,Hyekyung P. Cho,Alice L. Rodriguez,Colleen M. Niswender,Weimin Peng,Jerri M. Rook,Sichen Chang,Anna L. Blobaum,Olivier Boutaud,Analisa Thompson Gray,Carrie K. Jones,P. Jeffrey Conn,Andrew S. Felts,Craig W. Lindsley,Kayla J. Temple

ACS MEDICINAL CHEMISTRY LETTERS（2024）

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Key words

Metabotropic Glutamate Receptor Subtype5,mGlu(5),Negative Allosteric Modulator(NAM),Structure-ActivityRelationship (SAR),Levodopa-Induced Dyskinesia,Alzheimer's Disease,Pain,VU6043653

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