Eight-year National Multicenter Experience on the Use of Glucarpidase As Effective Rescue Therapy for Delayed Methotrexate Elimination after High-Dose Methotrexate Cycles Administered in Children with Hemato-Oncological Diseases

Nicolò Peccatori, Marta Coppola,Antonella Colombini,Daniela Silvestri,Nicoletta Bertorello,Valentina Kiren,Fraia Melchionda,Rosamaria Mura,Daniela Onofrillo, Simona Gobbi,Raffaele Mattera,Luciana Vinti,Tommaso Casini,Nicola Santoro,Domenico Sperlì,Carmelita D’Ippolito,Valentino Conter,Andrea Biondi,Carmelo Rizzari

EJC Paediatric Oncology（2025）

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Key words

methotrexate,glucarpidase,carboxypeptidase G2,delayed methotrexate elimination,acute kidney injury,acute lymphoblastic leukemia,non-Hodgkin lymphoma,child

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