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Design, Synthesis, and Structure-Activity Relationship Studies of Triazolo-Pyrimidine Derivatives As WRN Inhibitors for the Treatment of MSI Tumors

Qibang Sui,Yuanyang Zhou, Manjia Li,Dan Wang,Rongrong Cui, Xiaoying Cai,Jia Liu, Xiaofeng Wang, Dan Teng,Jingyi Zhou,Hui Hou,Sulin Zhang,Mingyue Zheng

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY（2025）

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Key words
Synthetic lethal,MSI tumors,WRN inhibitors,Triazolo-pyrimidine derivatives
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