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Structure-based Optimization of Isoaurostatin As Novel PDE4 Inhibitors with Anti-Fibrotic Effects

Yi-You Huang,Xiang Luo, Kai Zhang, Yulan Liang, Furong Zhang,Guochao Liao, Shenghong Xie, Pei-Luo Huang, Siyu Hou,Qian Zhou,Yong Zou,Hai-Bin Luo

Chinese Chemical Letters（2024）

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关键词
PDE4,Isoaurone,Structural optimization,Crystal structure,IPF
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