Optimizing the Detection of N-nitrosamine Mutagenicity in the Ames Test

Robert H. Heflich,Michelle E. Bishop,Roberta A. Mittelstaedt,Jian Yan, Sharon K. Guerrero, Audrey M. Sims, Kamela Mitchell, Nyosha Moore,Xilin Li,Nan Mei,Rosalie K. Elespuru, Sruthi T. King,David A. Keire,Naomi L. Kruhlak, Robert T. Dorsam,Andre S. Raw, Karen L. Davis Bruno,Timothy J. McGovern,Aisar H. Atrakchi

REGULATORY TOXICOLOGY AND PHARMACOLOGY（2024）

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关键词

Ames test,Drug impurities,Small-molecule N -Nitrosamines,Nitrosamine drug substance-related impurities,Hamster liver S9,Rat liver S9,Preincubation,Acceptable intake limit,Carcinogenic potency categorization approach,Mutagenicity dose-response ranking

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