Development of a DNA-encoded Library Screening Method “DEL Zipper” to Empower the Study of RNA-targeted Chemical Matter

Zhongyao Ma, Bin Zou, Jiannan Zhao, Rui Zhang, Qiaoqiao Zhu, Xiaofeng Wang, Linan Xu, Xiang Gao, Xinyue Hu,Wei Feng, Wen Luo, Min Wang,Yunyun He, Zhifeng Yu,Weiren Cui,Qi Zhang,Letian Kuai,Wenji Su

SLAS DISCOVERY（2025）

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Key words

DNA encoded library,RNA targeting drug discovery,Small molecule,DNA-RNA interaction,Affinity selection,G-quadruplex

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