Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM)

Julie L. Engers, Logan A. Baker,Sichen Chang,Vincent B. Luscombe,Alice L. Rodriguez,Colleen M. Niswender,Hyekyung P. Cho,Michael Bubser,Analisa Thompson Gray,Carrie K. Jones,Weimin Peng,Jerri M. Rook,Thomas M. Bridges,Olivier Boutaud,P. Jeffrey Conn,Darren W. Engers,Craig W. Lindsley,Kayla J. Temple

ACS CHEMICAL NEUROSCIENCE（2024）

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关键词

Muscarinic acetylcholine receptor (mAChR),Muscarinicacetylcholine receptor subtype 4 (M-4),Positiveallosteric modulator (PAM),Structure-activity relationship(SAR),Schizophrenia,Parkinson's disease,Alzheimer's disease

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