Systemic T-cell Activation and Interferon-Γ Activity in Indeterminate Severe Hepatitis (ish) Are Reminiscent of Hemophagocytic Lymphohistiocytosis (HLH): Implications for T-cell and Interferon-Γ Directed Therapies.

Thinh H. Nguyen,Prakash Satwani,Deepak Kumar,Urvi Kapoor,Sakshi Malik,Chengyu Prince, Taylor Montminy, Kristi Smiley,Mercedes Martinez,Dana Goldner,Rebecca Marsh,Helen E. Remotti,Ladan Fazlollahi,Heather B. Rytting,Rene Romero,Shanmuganathan Chandrakasan

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY（2025）

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Key words

Indeterminate severe hepatitis,hemophagocytic lymphohistiocytosis,indeterminate pediatric acute liver failure,CD8+T-cell activation,soluble interleukin-2 receptor,ferritin,posthepatitis aplastic anemia

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