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Structure-Activity Relationship of Potent, Selective, and Orally Bioavailable Molecular Glue Degraders of CK1α

Gisele Nishiguchi,Elizabeth A. Caine,Kevin Mcgowan, Zhe Shi,Anup Aggarwal,Anand Mayasundari,Jeanine Price,Lei Yang,Yong Li,Xiang Fu,Lauren G. Mascibroda,Sourav Das,Danette L. Daniels,Marjeta Urh,Jeffery M. Klco,Kristin M. Riching,Zoran Rankovic

ACS Medicinal Chemistry Letters（2024）

Cited 1|Views4
Key words
CRBN,CK1 alpha,GSPT1,IKZF1,Molecular glues,IMiDs,Targeted protein degradation
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