Targeting PYK2 with Heterobifunctional T6BP Helps Mitigate MASLD and MASH-HCC Progression

Minxuan Xu,Junjie Zhao,Liancai Zhu,Chenxu Ge,Yan Sun, Ranran Wang, Yuanyuan Li,Xianling Dai,Qin Kuang,Linfeng Hu,Jing Luo,Gang Kuang,Yanrong Ren,Bochu Wang, Jun Tan,Shengbin Shi

JOURNAL OF HEPATOLOGY（2025）

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关键词

TRAF6-binding protein (T6BP),Protein tyrosine kinase 2 beta (PYK2),Metabolic dysfunction-associated steatotic liver disease (MASLD),Metabolic dysfunction-associated steatohepatitis (MASH),MASLD-related HCC (MASH-HCC)

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