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Design, Synthesis and Biological Evaluation of Thieno[3,2-C]pyrazol-urea Derivatives As Potent Glycogen Synthase Kinase 3β Inhibitors Based on the DFG-out Conformation.

Ning Yan, Hong-Yan Liu,Ting-Ting Kong, Zi-Hao Kong,Ling-Yun Li, Xin Ma, Yan-Li Zeng, Mei-Jun Wang,Long-Qian Tang,Cheng-Mei Zhang,Zhao-Peng Liu,Chao Liu

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS(2024)

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Key words
GSK-3 beta,GSK-3 beta inhibitors,Type II GSK-3 beta inhibitors,DOLPHIN protocol,DFG-out conformation
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