The Pyrazolo[4,3-C]pyrazole Core As a Novel and Versatile Scaffold for Developing Dual DYRK1A-CLK1 Inhibitors Targeting Key Processes of Alzheimer’s Disease Pathology.
European Journal of Medicinal Chemistry Reports（2024）
Key words
Kinase inhibitors,Metadynamics,pyrazolo[4,c ]pyrazoles,Solvent mapping,Alzheimer's disease,Free energy perturbation,beta-amyloid aggregation inhibitors,Multi-target-directed ligands
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