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Evolution of SARS-CoV-2 Spike Trimers Towards Optimized Heparan Sulfate Cross-Linking and Inter-Chain Mobility

Jurij Froese, Marco Mandalari,Monica Civera,Stefano Elli,Isabel Pagani,Elisa Vicenzi, Itzel Garcia-Monge,Daniele Di Iorio, Saskia Frank,Antonella Bisio,Dominik Lenhart,Rudolf Gruber,Edwin A. Yates,Ralf P. Richter,Marco Guerrini,Seraphine V. Wegner,Kay Grobe

SCIENTIFIC REPORTS（2024）

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Key words
COVID-19,SARS-CoV-2,Heparan sulfate,Heparin,S-protein,Intersegmental transfer
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