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Head-to-head Comparison of Aptamer- and Antibody-Based Proteomic Platforms in Human Cerebrospinal Fluid Samples from a Real-World Memory Clinic Cohort

Raquel Puerta,Amanda Cano,Pablo Garcia-Gonzalez,Fernando Garcia-Gutierrez,Maria Capdevila,Itziar de Rojas,Claudia Olive, Josep Blazquez-Folch,Oscar Sotolongo-Grau,Andrea Miguel,Laura Montrreal,Pamela Martino-Adami, Asif Khan,Adelina Orellana,Yun Ju Sung,Ruth Frikke-Schmidt,Natalie Marchant,Jean Charles Lambert,Maitee Rosende-Roca,Montserrat Alegret,Maria Victoria Fernandez,Marta Marquie,Sergi Valero,Lluis Tarraga,Carlos Cruchaga,Alfredo Ramirez,Merce Boada,Bart Smets,Alfredo Cabrera-Socorro,Agustin Ruiz

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES（2025）

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Key words
proteomics,Olink,SomaScan,Alzheimer’s disease,mild cognitive impairment,cerebrospinal fluid,biomarkers
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