A Simulation Study of the Impact of Drug-Ikr Binding Mechanisms on Biomarkers of Proarrhythmic Risk Reveals a Crucial Role in Reverse Use Dependence of Action Potential Duration and a Marked Influence on the Vulnerable Window
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE（2025）
Key words
Action potential triangulation,Instability,Transmural dispersion of repolarization,Computer modelling,hERG blockers,Class III drugs,Proarrhythmic risk,Drug safety
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