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PARP11 Inhibition Inactivates Tumor-Infiltrating Regulatory T Cells and Improves the Efficacy of Immunotherapies

Raghavendra Basavaraja,Hongru Zhang,Agnes Holczbauer,Zhen Lu,Enrico Radaelli,Charles-Antoine Assenmacher,Subin S. George, Vamshidhar C. Nallamala,Daniel P. Beiting,Mirella L. Meyer-Ficca,Ralph G. Meyer,Wei Guo,Yi Fan,Andrew J. Modzelewski,Vladimir S. Spiegelman, Michael S. Cohen,Serge Y. Fuchs

Cell Reports Medicine（2024）

Cited 0|Views5
Key words
PARP11,Treg cells,tumor microenvironment,immunotherapy,PARP11 inhibitor,ITK7
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