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Applying Two Approaches to Detect Unmeasured Confounding Due to Time-Varying Variables in a Self-Controlled Risk Interval Design Evaluating COVID-19 Vaccine Safety Signals, Using Myocarditis As a Case Example

Sophie H. Bots,Svetlana Belitser,Rolf H. H. Groenwold,Carlos E. Duran,Judit Riera-Arnau,Anna Schultze,Davide Messina,Elena Segundo,Ian Douglas,Juan Jose Carreras,Patricia Garcia-Poza,Rosa Gini,Consuelo Huerta,Mar Martin-Perez,Ivonne Martin,Olga Paoletti,Carlo Alberto Bissacco,Elisa Correcher-Martinez,Patrick Souverein, Arantxa Urchueguia-Fornes,Felipe Villalobos,Miriam C. J. M. Sturkenboom,Olaf H. Klungel

American journal of epidemiology（2025）

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Key words
pharmacoepidemiology,negative controls,quantitative bias analysis,COVID-19 vaccine safety,self-controlled risk interval design
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