Conformational Modulation of a Mobile Loop Controls Catalysis in the (Βα)8-Barrel Enzyme of Histidine Biosynthesis HisF

Enrico Hupfeld,Sandra Schlee,Jan Philip Wurm,Chitra Rajendran,Dariia Yehorova,Eva Vos,Dinesh Ravindra Raju,Shina Caroline Lynn Kamerlin,Remco Sprangers,Reinhard Sterner

JACS AU（2024）

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(beta alpha)(8)-barrel,protein dynamics,loop motion,enzyme kinetics,enzyme mechanism,stopped-flow analysis,nuclear magnetic resonance spectroscopy,molecular dynamics simulation

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